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目的:研究血管紧张素转换酶抑制药(ACEI)和血管紧张素受体拮抗药(ARB)对2型糖尿病肾病患者肾功能的保护作用。方法:选择有肾功能损害的糖尿病病人90例,在常规糖尿病治疗的同时,随机分成3组,分别给予ACEI、ARB、ACEI合并ARB治疗,观察治疗前后24h尿蛋白的变化。结果:3组患者治疗后尿蛋白排泄均减少,差别有统计学意义(P<0.05),而联合治疗组与其他两组相比,差别有统计学意义(P<0.05)。结论:ACEI和ARB联用能更好地起到肾脏保护作用。
AIM: To investigate the protective effects of angiotensin-converting enzyme inhibitor (ACEI) and angiotensin II receptor blocker (ARB) on renal function in patients with type 2 diabetic nephropathy. Methods: Ninety diabetic patients with renal dysfunction were selected and randomly divided into three groups at the same time of routine diabetes treatment. ACEI, ARB and ACEI combined with ARB were respectively administered to observe the changes of urinary protein in 24 hours before and after treatment. Results: Urine protein excretion decreased after treatment in all three groups (P <0.05), but the difference between the two groups was statistically significant (P <0.05). Conclusion: Combination of ACEI and ARB can better protect the kidneys.