论文部分内容阅读
尾加压素Ⅱ(UⅡ)是最早从鱼尾部下垂体中分离出的血管活性肽,近来已从人体中克隆出来,通过作用于其特异性受体G蛋白耦联受体参与许多生物学效应,其中包括收缩/舒张血管,促内皮细胞、血管平滑肌细胞、心肌纤维细胞增殖及抑制胰岛素分泌等。UⅡ不仅与许多心血管疾病如高血压、充血性心力衰竭、冠心病和动脉粥样硬化有关,而且研究发现,糖尿病患者血液中UⅡ含量升高,同时有许多研究表明,与2型糖尿病大血管病变、糖尿病肾病、糖尿病视网膜病变、糖尿病足等慢性并发症的发生均有关。
Urotensin II (UII), the earliest vasoactive peptide isolated from the tail pituitary gland, has recently been cloned from the human body and is involved in many biological effects by acting on its receptor G-protein coupled receptors , Including contraction / relaxation of blood vessels, promoting endothelial cells, vascular smooth muscle cells, myocardial fibroblasts proliferation and inhibition of insulin secretion. UII is not only associated with many cardiovascular diseases such as hypertension, congestive heart failure, coronary heart disease and atherosclerosis, and the study found that U II levels in the blood of diabetic patients increased, while many studies have shown that with large blood vessels of type 2 diabetes Lesions, diabetic nephropathy, diabetic retinopathy, diabetic foot and other chronic complications are related.