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本研究旨在明确慢性肾功能衰竭时大剂质速尿是否能增加肾小球滤过率。7例稳定性慢性肾功能衰竭病人,住院20天,每天留24小时尿作检查。头10天维持病人液体平衡,不予利尿荆;后10天,给予10速尿口服,并根据24小时尿的情况,给予补充液体和电解质。每日测定血浆和尿中的钠、钾、尿素、肌酐以及渗透浓度。治疗期间观察到病人水、钠、钾排泄量明显增加,p 值分别<0.01,<0.01,<0.05;血压、体重、血肌酐、内生肌酐清除率、尿素清除率和肌酐、尿素的总排泄量,以及血浆钠、钾或渗透浓度均无明显变化。结果表明,速尿1 g 用于稳定性慢性肾功能衰竭病人,对其固有的肾功能无任何影响,但可以明显增加
The aim of this study was to determine whether high-dose furosemide increases glomerular filtration rate in patients with chronic renal failure. Seven patients with stable chronic renal failure, hospitalized 20 days, 24 hours a day to stay for 24 hours. The first 10 days to maintain the patient’s fluid balance, not diuretic Jing; 10 days after giving 10 quick urine oral administration, and according to the 24-hour urine situation, given fluid and electrolytes. Daily determination of plasma and urine sodium, potassium, urea, creatinine and osmolality. During treatment, patients were observed significantly increased water excretion of sodium, potassium, p values were <0.01, <0.01, <0.05; blood pressure, body weight, serum creatinine, creatinine clearance, urea clearance and creatinine, total excretion of urea Volume, and plasma sodium, potassium or osmotic concentration did not change significantly. The results showed that furosemide 1 g for chronic renal failure patients with stable, its inherent renal function without any effect, but can be significantly increased