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IL- 1是一重要的炎性细胞因子。它参与介导类风湿关节炎、系统性红斑狼疮等自身免疫性疾病的病理过程。IL- 1受体家族有 IL- 1RI、IL- 1R 和 IL- 1RAc P(IL- 1receptor accessory protein,白细胞介素 1受体辅助蛋白 )。IL- 1RI是功能性受体 ,IL- 1R 是“伪受体”。IL- 1RAc P是近年来发现的参与 IL- 1信号传导的重要分子 ,它的表达与否与细胞对 IL- 1的反应相关。本文综述了 IL- 1RAc P对 IL- 1与 IL- 1R结合的影响 ,IL- 1RAc P参与的信号转导及其可能的调节机制
IL-1 is an important inflammatory cytokine. It is involved in the pathogenesis of autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus. The IL-1 receptor family has IL-1RI, IL-1R and IL-1RAc P (IL-1 receptor accessory protein). IL-1RI is a functional receptor and IL-1R is a “pseudo receptor.” IL-1RAc P is an important molecule involved in IL-1 signaling in recent years. Its expression is related to the response of cells to IL-1. This article reviews the effects of IL-1RAc P on the binding of IL-1 to IL-1R, the signal transduction involved in IL-1RAc P and its possible regulatory mechanisms