【摘 要】
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Heshouwu, the tuberous root of Polygonum multiflorum Thunb, is widely used as traditional Chinese herbal medicine for thousands of years.This herb has been demonstrated to possess varieties of pharmac
【机 构】
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Guangdong Provincial Key Laboratory of New Drug Screening, Biopharmaceutics,School of Pharmaceutical
【出 处】
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2016何首乌及其制剂临床价值与精准用药高级研讨会
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Heshouwu, the tuberous root of Polygonum multiflorum Thunb, is widely used as traditional Chinese herbal medicine for thousands of years.This herb has been demonstrated to possess varieties of pharmacologicol effects, such as hair-blacking,anti-aging, anti-atherosclerosis and hepato-protective activities.However, there are increasing reports on the toxicity of Heshouwu.The main target organs of the toxicity are liver and kidney particularly in high doses and with long-term use.Usually, these toxic effect were thought to be induced by emodin, an anthraquinone component of Heshouwu.The mechanisms involved in Heshouwu derived toxicity are not well understood.The aim of this study was to find out the mechanisms of causing hepatic /renal toxicity of emodin and detoxification ways.
其他文献
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