NUCLEOSIDE相关论文
Amicetin and congeners constitute a small family of complex pyrimidine nucleosides,which exhibit strong antibiotic activ......
Determination of modified nucleosides in Escherichia coli by Liquid Chromatography-Electrospray Ioni
To date, there are about 100 modified nucleosides (MNs) have been identified in RNA species and the majority of them wer......
Monofluoromethylation has attracted substantial attention in organic synthesis, owing to the increasing important applic......
Long-term antiviral treatment of chronic hepatitis B patients has been proven to be beneficial in reducing liver-related......
Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs?An in vitro and in vivo D
Remdesivir (RDV) is the only US Food and Drug Administration (FDA)-approved drug for treating COVID-19.However,RDV can o......
Fluorescent supramolecular nucleoside-based organogels or hydrogels have attracted increasing attention owing to their t......
Effects of different anti-HIV therapies on progression of hepatitis C in HCV /HIV-coinfected patient
Objective To investigate the effect of protease inhibitors(PIs)-or non-nucleoside reverse transcriptase inhibitors(NNR-T......
The effect of non-alcoholic fatty liver disease on virologic response in patients with hepatitis B e
Objective To investigate the effect of non-alcoholic fatty liver disease(NAFLD)on virologic response in chronic hepatiti......
Viral infection parameters not nucleoside analogue itself correlates with host immunity in nucleosid
AIM:To determine the relationship between host immunity and the characteristics of viral infection or nucleoside analogu......
Treatment of chronic hepatitis B(CHB) has markedly improved in the last 15 years due to the availability of direct antiv......
The ultimate goals of treating chronic hepatitis B(CHB)is prevention of hepatocellular carcinoma(HCC)and hepatic decompe......
AIM:To hypothesize that beta-7 integrin affects cellularmigration of both,lymphocytes and enterocytes.METHODS:The nucleo......
AIM: To verify the hypothesis that caspase-8(Casp8), which regulates cellular apoptosis and necroptosis, is critically i......
Highly active antiretroviral therapy dysregulates proliferation and differentiation of human pre-adi
AIM To investigate the mechanism(s) by which potential effects of multi-drug highly-active antiretroviral therapy contri......
Recombinant Escherichia coli pUDP,which overexpressed uridine phosphorylase(UPase),was constructed.0.5 mmol·L 1lactose ......
An efficient and regioselective synthesis of N-9 alkoxyalkylated purine nucleoside derivatives was achieved via the N-al......
A naturally occurring nucleoside disulfide,9-(5’-deoxy-5’-thio-β-D-xylofuranosyl)adenine disulfide,was first synthesi......
Modified deoxy-and ribo-nucleoside triphosphates are chemically synthesized in multiple steps due to the protection and ......
Synthesis of nucleoside tetraphosphates and dinucleoside pentaphosphates from nucleoside phosphoropi
A novel and efficient method for the preparation of nucleoside 5’-tetraphosphates has been developed by coupling nucleo......
AIM: To analyze the clinical features and risk factors of adverse reactions associated with telbivudine. METHODS: Clinic......
Up to date, there are two types of drugs approved to treat hepatitis B: interferons and nucleos (t) ide analogues. Howev......
QSAR Studies on 6-(1-Naphthylmethyl) Substituted S-DABO Derivatives as Novel Non-nucleoside HIV-1 Re
The AM1 and B3LYP methods were employed to calculate the structural pro-perties of 20 6-(1-naphthylmethyl) substituted S......
The selenium derivatization of nucleic acids and nucleic acid-protein complexes has provided a powerful tool to solve ph......
A disulfde-modifed nucleoside was designed and synthesized. After loading the modifed nucleoside on controlled pore glas......
Searching for more safe and effective agents for HIV treatments is still an urgent topic worldwide.Based on our continuo......
Diabetic retinopathy is a leading cause of blindness among working-age adults.Despite many years of research,treatment o......
There is an urgent need for new antifungal agents to treat or combat fungal infection in humans and plants.Antifungal nu......
Emerging Trends of Drug-Resistant HIV-1 among Drug-Treated Patients in Former Blood Donors in Hubei,
This study aimed to evaluate emerging trends of drug resistance to nucleoside reverse transcriptase inhibitors (NRTIs) a......
Pyrosequencing for detection of drug resistant relevant mutation in the polymerase gene of hepatitis
Objective To explore the accuracy and clinical application of pyrosequencing for detection of drug resistant relevant mu......
Oral antiviral agents have been developed in the last two decades for the treatment of chronic hepatitis B(CHB).However,......
Objective To study resistance evolution pathway of HIV-1 CRF_BC under drug selection pressure,and compare it with B subt......
Prevalence and patterns of drug-resistance mutations among HIV-1 patients infected with CRF07_BC str
Little information is available on the prevalence of drug-resistance mutations in patients harboring the human immunodef......
Interaction of 10-methylacridinium iodide (MAI) as fluorescence probe with nucleobases,nucleosides and nucleic acids has......
目的分析吉林市HIV感染者中HIV-1型对常用治疗药物的基因型耐药情况。方法采集吉林市接受抗病毒治疗的HIV-1感染者血样,提取RNA,采......
Virological response and resistance mutations to NS3/4A inhibitors in hepatitis C virus-human immuno
AIM: To evaluate virological response to telaprevir or boceprevir in combination with pegylated interferon and ribavirin......
Wheat rosette stunt virus （WRSV） contains an RNA-dependent RNA polymerase. The RNA polymerase activity is associated with ......
Aggressive restenosis after percutaneous intervention in two coronary loci in a patient with human i
A 54-year-old black African woman, 22 years human immunodeficiency virus(HIV)-positive, presented with an acute coronary......
慢性心力衰竭(chronic heart failure,CHF)与β肾上腺素受体/G蛋白耦联受体信号转导系统变化、环磷酸腺苷(cyclic adenosine monop......
LC-ESI-MS method was used to analyze the formed di-and tri-peptide hi the reaction system of N-(O,O-diisopropyl)phospho......
The title compound, C23H42N2O8Si2, Mr=530.77, crystallizes in the monoclinic system, space group P21, with a=10.577(5), ......
The chemical synthesis of Guanine arabinoside(ara-G)is extremely complex,time-consuming,and se- riously polluted.A two-s......
Aggregation-induced emission luminogens(AIEgens)have been used in biomacromolecules detection.Herein,TPE-dC and TPE-dU a......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside......
Protective effect of taurine on hypochlorous acid toxicity to nuclear nucleoside triphosphatase in i
AIM:Taurine has been shown to be an effective scavengerof hypochlorous acid (HOCl).The role of HOCl is wellestablished ......
AIM:To explore the inhibition of β-L-D4A on hepatitis B virus(HBV) in 2.2.15 cells derived from HepG2 cells transfecte......
Sequential changes of serum ferritin levels and their clinical significance in lamivudine-treated pa
AIM:To study the sequential changes of serum ferritin levelsin lamivudine-treated patients with chronic viral hepatitis......
Objective: To study the clinical features of chronic hepatitis B (CHB) patients with tyrosine-methionine-aspartate- aspa......
AIM:To investigate the safety of β-L-D4A on DNA polymeraseα. METHODS:Ion exchange chromatography was used to separate ......
