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钙拮抗剂能阻断细胞的钙内流,减轻缺血时的细胞损伤,改善血液动力学状态,是近年来研究缺血组织损伤的发病机制与治疗方面的一大进展。在心血管疾病,周围血管疾病,脑血管疾病和胃肠道功能紊乱、血小板功能紊乱、出血及哮喘等方面应用钙拮抗剂都收到了明显的效果。近年来一些作者还进行了钙拮抗剂对肾脏生理及急性肾功能衰竭的影响的研究,取得了不小的进展。本文对此作一综述。
Calcium antagonists can block the influx of calcium, reduce cell damage during ischemia and improve hemodynamic status. It is a great progress in the study of the pathogenesis and treatment of ischemic tissue injury in recent years. In the cardiovascular disease, peripheral vascular disease, cerebrovascular disease and gastrointestinal disorders, platelet dysfunction, bleeding and asthma and other aspects of the application of calcium antagonists have received significant results. In recent years, some authors also conducted a study of the effects of calcium antagonists on renal physiology and acute renal failure, and made no small progress. This article gives a summary of this.