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目的观察头孢他啶联合左氧氟沙星对心力衰竭合并肺部感染患者炎症因子表达水平的影响。方法收集110例心力衰竭合并肺部感染患者的临床资料,均采用头孢他啶联合左氧氟沙星作为抗炎方案,分别取治疗前、连续治疗3d后、连续治疗1周后外周静脉血,测定血清降钙素原(procalcitonin,PCT)、C反应蛋白(C-reactionprotein,CRP)的表达水平,并行统计学对比。结果 110例患者连续治疗1周后血清PCT(2.4±0.5)ng/ml,CRP(19.4±2.3)mg/L,两项数据均为最低水平,其次为治疗3d,治疗前二者血清表达水平最高,分别为PCT(11.2±1.4)ng/ml、CRP(104.4±9.0)mg/L,不同时间点测定数据比较,差异均存在统计学意义(P<0.05)。结论头孢他啶联合左氧氟沙星治疗心力衰竭合并肺部感染患者,能显著降低患者血清PCT、CRP等炎症因子的表达水平,有效纠正机体感染状态,改善预后,值得临床推广应用。
Objective To observe the effect of ceftazidime and levofloxacin on the expression of inflammatory cytokines in patients with heart failure and pulmonary infection. Methods The clinical data of 110 cases of patients with heart failure and pulmonary infection were collected. Both ceftazidime and levofloxacin were used as anti-inflammatory regimen. Peripheral venous blood was obtained after 1 week of continuous treatment before treatment and 3 days after continuous treatment. Serum procalcitonin The expression of procalcitonin (PCT) and C-reaction protein (CRP) were compared statistically. Results The serum levels of PCT (2.4 ± 0.5) ng / ml and CRP (19.4 ± 2.3) mg / L in 110 patients after one week of treatment were the lowest, followed by those after 3 days of treatment, respectively (P <0.05). The difference was statistically significant (P <0.05). The difference was statistically significant (P <0.05). Conclusion Ceftazidime combined with levofloxacin in patients with heart failure and pulmonary infection can significantly reduce the serum PCT, CRP and other inflammatory cytokines expression level, effectively correct the body infection and improve prognosis, it is worthy of clinical application.