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分泌睾酮的卵巢瘤或肾上腺瘤罕见,但已弄清是男性化的原因。许多这类患者,其雄激素分泌受到促性腺激素的刺激,而对于ACTH、雌激素和地塞米松的反应则变异较大。本文描述一例患卵巢Leydig细胞瘤的绝经后妇女,其血清睾酮水平在注射一种促性腺激素释放激素(GnRH)的高活件类似物(活性约为天然GnRH的40倍)后明显降低。患者60岁,未婚,声音低哑,多毛。绝经为45岁,无绝经后出血。触诊卵巢不大,血压140/90mmHg,无库兴氏征。用地塞米松抑制试验排除了库兴氏病。血清睾酮水平持续且明显地升高,任意的四次基值为;15.1,16.7,16.2和15.1nmol/l。血清雄甾烯二酮为2.4 n mol/l,双氢异雄酮硫酸盐
Ovarian tumors or adrenomas that secrete testosterone are uncommon but have been identified as masculine. In many of these patients, the androgen secretion is stimulated by gonadotropins, whereas the responses to ACTH, estrogen and dexamethasone vary greatly. This article describes a postmenopausal woman with ovarian Leydigocytoma whose serum testosterone levels were significantly reduced after injection of a high activity analogue of a gonadotropin-releasing hormone (GnRH) (approximately 40 times more active than native GnRH). Patient 60 years old, unmarried, low-sounding, hirsutism. Menopause is 45 years old, without postmenopausal bleeding. Palpation of the ovary is not large, blood pressure 140 / 90mmHg, no library Xing sign. Cushing’s disease was ruled out with dexamethasone suppression test. Serum testosterone levels were consistently and significantly elevated, with any four basis values being; 15.1, 16.7, 16.2 and 15.1 nmol / l. Serum androstenedione was 2.4 n mol / l, dihydroxyproserone sulfate