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目的探讨类风湿性关节炎合并肺间质病变(RA-ILD)发病的相关因素。方法 RA患者81例,合并ILD患者作为RA-ILD组(38例),未合并ILD为RA组(43例),比较两组血清类风湿因子(RF)、抗环瓜氨酸肽(CCP)抗体和葡萄糖-6-磷酸异构酶(GPI)的差异。结果 RA-ILD组血清RF为(581.49±106.62)IU/ml,抗CCP抗体阳性率为88.62%,GPI为(1.44±1.36)μg/ml,均高于RA组的(377.79±155.77)IU/ml、64.87%、(1.05±1.21)μg/ml(P<0.05)。而两组血清RF阳性率和抗CCP抗体水平均无统计学差异[(84.47%vs.71.88%)和(786.59±546.57)IU/ml vs.(782.21±605.21)IU/ml](P>0.05)。结论血清RF水平、抗CCP抗体阳性率和GPI水平高的RA患者较易合并ILD。
Objective To investigate the related factors of rheumatoid arthritis with interstitial lung disease (RA-ILD). Methods Eighty-one patients with RA were enrolled in this study. Serum rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) Differences in antibodies and glucose-6-phosphate isomerase (GPI). Results The serum RF of RA-ILD group was 581.49 ± 106.62 IU / ml, the positive rate of anti-CCP antibody was 88.62% and the GPI was 1.44 ± 1.36 μg / ml, which were significantly higher than that of RA group (377.79 ± 155.77) IU / ml, 64.87%, (1.05 ± 1.21) μg / ml (P <0.05). There was no significant difference in serum RF positive rate and anti-CCP antibody level between the two groups [(84.47% vs.71.88%) and (786.59 ± 546.57) IU / ml vs. (782.21 ± 605.21) IU / ml] ). Conclusion Serum RF level, anti-CCP antibody positive rate and high GPI level of RA patients more likely to merge with ILD.