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【赵涛,Hiroshi Harada,Yuji Teramura,等。J Control Release,2010,144(1):109-114】对正常组织的侵袭和转移是恶性肿瘤的两大特征。肿瘤细胞对周围组织的侵袭程度和是否发生转移是肿瘤恶性程度的重要标志。基质金属蛋白酶(matrix metalloproteinases,MMPs)是降解细胞外基质(extracellular matrix,ECM)中各种蛋白质成分以及破坏组织重塑的特异性内肽酶类,能够破坏组织学屏障,在肿瘤侵袭和转移中起关键性作用。基质金属蛋白酶2(MMP2)和膜型基质金属蛋白酶-1(membrane-type 1 MMP,MT1-MMP)作为基质金
[Zhao Tao, Hiroshi Harada, Yuji Teramura, et al. J Control Release, 2010,144 (1): 109-114】 Invasion and metastasis to normal tissues are two major characteristics of malignant tumors. Tumor cells on the surrounding tissue invasion and the occurrence of metastasis is an important indicator of tumor malignancy. Matrix metalloproteinases (MMPs), which are specific endopeptidases that degrade various protein components in the extracellular matrix (ECM) and disrupt tissue remodeling, can destroy the histological barrier and promote tumor invasion and metastasis Play a key role. Matrix metalloproteinase 2 (MMP2) and membrane-type 1 MMP (MT1-MMP) as matrix gold