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目的：探讨未成年起病女性狼疮性肾炎（ Ｌ Ｎ） 的临床和预后。 方法：回顾性分析３１ 例未成年起病女性 Ｌ Ｎ 的临床、病理和预后，并与同期４５９ 例育龄妇女及６９ 例男性患者比较。 结果：①在４９５ 例女性患者中，未成年起病（１４ 岁以前） 患者３１ 例，占女性病例的６２６ ％ ，同期６９ 例男性患者中有４ 例１４ 岁前起病，未成年起病男女比例为１∶７７５ ；②未成年女性患者中有６７７４ ％ 以肾脏病变起病，而育龄女性半数以肾外表现起病，且从出现肾外病变到发生肾脏病变间的间期较长（ 育龄女性平均为２０２０ 个月，未成年女性为１０３８ 个月） ；③未成年女性Ⅳ型 Ｌ Ｎ 占７４１９ ％ ，其蛋白尿、血尿及肾功能损害也较重；此外还较常累及心脏、中枢神经及血液系统；④未成年女性 Ｌ Ｎ 预后差，随访５ 年后肾功能稳定率为３６５７ ％ ，同期育龄妇女有８２６８ ％ 保持肾功能稳定；⑤未成年女性 Ｌ Ｎ 的上述表现与育龄女性有较大差别，而与男性较为接近。 结论：未成年起病的女性 Ｌ Ｎ 较为少见，但其大多为弥漫增生型，病变重、预后差，而与男性 Ｌ Ｎ 较为相似。
Objective: To investigate the clinical and prognosis of juvenile onset lupus nephritis (L N) in children. Methods: A retrospective analysis of 31 cases of juvenile onset L N clinical, pathological and prognosis, and 459 cases of women of childbearing age and 69 cases of men compared with the same period. Results: (1) Among 495 female patients, 31 cases of juvenile onset (before 14 years old) accounted for 626% of female cases, and 4 of 69 cases of male patients onset before 14 years old, The ratio of male to female was 1: 775; ② 6774% of the undead female patients developed renal disease, while half of women of childbearing age were found to be exogenous to the kidney, and from the appearance of extrarenal lesions to the occurrence of renal lesions (20-20 months for women of childbearing age and 10.38 months for children); (3) The L N of juvenile female patients accounted for 74.19%, and the proteinuria, hematuria and renal dysfunction Heavier; in addition, the heart, central nervous system and hematological system were involved more frequently. ④LN patients had poor prognosis. After 5 years of follow-up, the stability of renal function was 3657% and 8268% of women of childbearing age maintained renal function (5) The above performance of underage female L N is quite different from that of women of childbearing age, but it is close to that of male. CONCLUSION: The incidence of L N in juvenile onset women is relatively rare, but most of them are diffuse hyperplastic, with severe disease and poor prognosis, which are similar to L N in men.