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目的:观察多巴酚丁胺早期应用在治疗肺炎合并脓毒症中的作用.方法选取2010年1月~2014年1月住院的肺炎合并脓毒症1个月至13岁患儿为研究对象,采用随机对照分组的方法进行研究.将确诊病例53例随机分为两组,治疗组26例,对照组27例,治疗组在治疗的同时给予多巴酚丁胺静滴,剂量2.5~10 ug/(kg.min),实验组则同时给予相应量的生理盐水(2.5~10 ug/(kg.min))以减少偏倚的发生.结果治疗组平均住院天数为(14.6±7.2)d,器官衰竭的发生率为15.38%(4/26),无死亡病例;对照组平均住院天数为(21.4±13.6)d,器官衰竭的发生率为37.04%(10/27),4例死亡病例.实验组与对照组治愈时间比较有统计学意义(t=2.89,P<0.01).两组器官衰竭发生率及病死率比较有统计学意义(P<0.05).结论早期给予多巴酚丁胺治疗肺炎合并脓毒症,可降低器官衰竭发生率,缩短住院天数,降低病死率. “,”Objective to observe the treatment effect on pneumonia compliacated with sepsis by early application of dobutamine. The pneumonia complicated with sepsis objects were selected from hospitalized children of 1 month to 13 years from Jan. 2010 to Jan. 2014. It employs randomized controlled method and divided the conifrmed 53 cases into two groups. The treatment group is with 26 cases and the other 27 cases is in the control group. The treatment group was given dobutamine infusion,( 2.5-10ug/(kg.min)) and the experimental group was given normal saline(2.5-10ug/ (kg.min)) .The results indicated that the treatment group has much more curative effect than control group. Its average hospital stay was (14.6 + 7.2) d, the organ failure incidence 15.38% (4/26) and no death case. But in the control group, the average hospital stay was (21.4 + 13.6) d, the incidence of organ failure 37.04% (10/27) and 4 death cases. The cure time experimental group and the control group comparison (employs t examine) exits statistically signiifcant (t=2.89,P〈0.01). And the organ failure and mortality rate distinction between two groups (using the chi square test) also has statistically signiifcant (the averageP〈0.05). Therefore, it can shorten the length of hospital stay, reduce the organ failure incidence and the mortality rate effectively by employing early dobutamine to treat pneumonia complicated with sepsis.