【摘 要】
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Defects in mitochondria are responsible for various ge-netic and acquired diseases. Mitochondrial transplantation, a method that involves introduction of healthy donor mi-tochondria into cells with dysfunctional mitochondria, could offer a novel approach
【机 构】
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Department of Medicine,Division of Gastroenterology-Hepatology,University of Connecticut Health Cent
论文部分内容阅读
Defects in mitochondria are responsible for various ge-netic and acquired diseases. Mitochondrial transplantation, a method that involves introduction of healthy donor mi-tochondria into cells with dysfunctional mitochondria, could offer a novel approach to treat such diseases. Some studies have demonstrated the therapeutic benefit of mitochondrial transplantation and targeted delivery in vivo and in vitro within hepatocytes and the liver. This review discusses the issues regarding isolation and delivery of mitochondria to hepatocytes and the liver, and examines the existing litera-ture in order to elucidate the utility and practicality of mito-chondrial transplantation in the treatment of liver disease. Studies reviewed demonstrate that mitochondrial uptake could specifically target hepatocytes, address the challenge of non-specific localization of donor mitochondria, and pro-vide evidence of changes in liver function following injection of mitochondria into mouse and rat disease models. While potential benefits and advantages of mitochondrial trans-plantation are evident, more research is needed to deter-mine the practicality of mitochondrial transplantation for the treatment of genetic and acquired liver diseases.
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