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对异搏停、汉防己甲素及硝苯吡啶３种钙通道阻滞剂（ＣＣＢ）分别增强Ｋ５６２细胞对足叶乙甙（ＶＰ１６～２１３）、阿霉素、三尖杉酯碱及长春新碱（ＶＣＲ）等４种化疗药物的敏感性进行比较研究，同时研究异搏停、汉防己甲素对耐药Ｋ５６２细胞（Ｋ５６２／ＶＰ１６细胞）对上述药物毒性增强作用。结果提示汉防己甲素作用最优，其次为异搏停，两者对Ｋ５６２／ＶＰ１６细胞毒性增强作用大于ＶＰ１６敏感的Ｋ５６２细胞。ＣＣＢ的抗耐药性作用在一定范围内的药物浓度中以及耐药白血病细胞中作用显著。ＣＣＢ与化疗药物合用表现一定程度毒性作用，但与两者单用的毒性改变相似，因此认为ＣＣＢ在增强化疗药物作用中有一定临床应用价值。
Effects of verapamil, tetrandrine and nifedipine on calcium channel blockers (CCB) enhanced the inhibitory effect of K562 cells on the expression of etoposide (VP16 ~ 213), doxorubicin, harringtonine and Changchun Xin (VCR) and other four kinds of chemotherapeutic drugs were compared. Meanwhile, the effect of verapamil and tetrandrine on drug-resistant K562 / K562 cells was studied. The results suggested that tetrandrine had the best effect, followed by verapamil, both of which enhanced the cytotoxicity of K562 / VP16 more than VP16-sensitive K562 cells. The anti-drug effect of CCB is evident in a range of drug concentrations and in drug-resistant leukemic cells. The combination of CCB with chemotherapeutics shows a certain degree of toxicity, but it is similar to the toxicity change of both alone. Therefore, it is considered that CCB has some clinical value in enhancing the effect of chemotherapeutic drugs.