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作者研究了14例伴LACT和抗前凝血酶活性的病人,其结论为血清内出现LACT与动脉或静脉血栓形成有明显的关系。作者共观察了29例(女25,男4)血清内伴LACT病人,29例均为严重型SLE(26例伴肾受累)。22例肾活检:15人示增殖性肾小球损害(9例为弥漫型,6例为局灶型),3人肾小动脉损害伴肾小球缺血,2人为膜性肾病,2人肾小球环间膜Ig沉积。4人因血小板减少未作肾活检。25人有严重的SLE肾外表现(22人肾受累),14人(48％)出现中枢神经系统疾病。27人用大剂量皮质类固醇治疗(12人合并环磷酰胺)。22人
The authors studied 14 patients with LACT and anti-pro-thrombin activity and concluded that there was a clear relationship between LACT and arterial or venous thrombosis in the serum. The authors observed 29 cases (female 25, male 4) of the serum with LACT patients, 29 cases were severe SLE (26 cases with involvement of the kidney). 22 cases of renal biopsy: 15 cases showed proliferative glomerular damage (9 cases were diffuse, 6 cases were focal), 3 cases of renal arteriolar injury with glomerular ischemia, 2 were membranous nephropathy, 2 Glomerular annulus membrane Ig deposition. 4 due to thrombocytopenia did not make a kidney biopsy. Twenty-five had severe extrarenal manifestations of SLE (22 renal involvement) and 14 (48%) had CNS disease. Twenty-seven were treated with high-dose corticosteroids (12 patients with cyclophosphamide). 22 people