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儿童严重急性营养不良(severe acute malnutrition,SAM)分为水肿(恶性营养不良)或非水肿(消瘦)两种形式,两者对心血管的长期影响尚不清楚。研究人员假设,SAM幸存者成年后的心血管结构和功能较儿童期无营养不良者差。方法:纳入116名已成年的SAM幸存者,其中54名为非水肿型,62名为水肿型,同时纳入45名年龄、性别、体质量指数相匹配的儿童期无营养不良的成人作为对照组。所有受试者均接受标准化人体学测量、血压测量、超声心动图和动脉张力测量。同时测定左心室质量指数、流出道内径、颈动脉参数和脉搏波传导速度,计算全身血管阻力。结果:受试者平均年龄为(28.8±7.8)岁,55%为男性。调整年龄、性别、身高、体质量后,与对照组相比,SAM幸存者左心室流出道内径、每搏输出量、心输出量、脉搏波
Severe acute malnutrition (SAM) is classified into two types: edema (malnutrition) or non-edema (emaciation). The long-term cardiovascular effects of both are not yet clear. The researchers hypothesized that the survivors of SAM survivors have less cardiovascular structure and function than those without childhood malnutrition. METHODS: One hundred and sixty-one adult SAM survivors were enrolled in this study. Among them, 54 were non-edematous and 62 were edematous. 45 children without malnutrition with age, gender and body mass index matched for malnutrition . All subjects underwent standardized anthropometric, blood pressure, echocardiographic, and arterial tension measurements. Simultaneous determination of left ventricular mass index, outflow tract diameter, carotid artery parameters and pulse wave velocity, calculate systemic vascular resistance. Results: The mean age of subjects was (28.8 ± 7.8) years and 55% were male. After adjusting for age, sex, height, and body mass, compared with the control group, the left ventricular outflow tract diameter, stroke volume, cardiac output, pulse wave