由平卧变为直立倾斜时血浆内皮素浓度增加,而随容量的增加内皮素浓度下降。本研究探讨压力感受反射的激活能否增加血浆内皮素浓度。下列对象直立倾斜位时测定血浆内皮素和加压素浓度:(1)正常人5例;(2)原发性植物神经功能不全所致,压力感受反射受损5例;(3)加压反射传入功能正常但有短暂交感传出缩血管抑制即血管迷走性晕厥7例;(4)垂体性尿崩症3例。直立倾斜时正常人的动 Plasma concentration of endothelin increased from supine to upright, and decreased with increasing volume. This study examined whether activation of baroreflex can increase plasma endothelin concentrations. Plasma concentrations of endothelin and vasopressin were measured in subjects with orthostatic tilt: (1) 5 normal individuals; (2) 5 patients with impaired baroreflex due to primary autonomic dysfunction; (3) Reflex normal function but brief sympathetic vasoconstrictive vasovagal syncope in 7 cases; (4) 3 cases of pituitary diabetes insipidus. Upright tilt of normal people’s move