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研究了刺激性接触性皮炎对4种理化性质不同的~(14)C标记化合物——氢化可的松(HC)、消炎痛(IM)、布洛芬(IB)和aci tretin(AC)经皮穿透的影响。以0.5%十二烷基硫酸钠(SLS)水溶液0.5ml及用2.5cm~2一封闭塑料小室置于无毛豚鼠背部作预处理24小时。同法以蒸馏水作对照。动物经SLS预处理可产生均匀、中度至强烈的红斑。用经皮水损耗试验(TEWL)在体内测定水分穿透性发现,处理组比对照组增加4.5倍。这是由于血流量增加,被刺激部位皮肤温度升高所致。另在SLS预处理24小时后处死豚鼠,取其背部全层皮肤。用饱和药物的十四
The effects of irritant contact dermatitis on four compounds labeled with 14 C, hydrocortisone (HC), indomethacin (IB), ibuprofen (IB) and aci tretin (AC) The effect of skin penetration. 0.5 ml of 0.5% sodium dodecyl sulfate (SLS) aqueous solution and a closed plastic cell of 2.5 cm2 were placed on the back of a hairless guinea pig for pretreatment for 24 hours. The same method with distilled water for control. Animals pre-treated with SLS produce a uniform, moderate to intense erythema. Determination of water penetration in vivo using the Transdermal Water Loss Test (TEWL) found a 4.5-fold increase in the treated group over the control. This is due to increased blood flow, skin irritation caused by elevated temperature. Another 24 hours after SLS pretreatment guinea pigs were killed, taking the full thickness of the back of the skin. Fourteen with saturated drugs