糖尿病母亲的新生儿先天异常比正常妊娠高3～5倍。糖尿病未得到很好控制的依据是糖化血红蛋白(HbAlc)增高,并与胎儿结构异常的危险性增高密切相关。此类异常中约一半为先天性心脏缺陷。Miller等发现首次HbAlc值高于8.5％时,患糖尿病母亲的新生儿先天异常的危险性明显升高。 研究对象来源于1985年1月～1992年4月就诊于加利福尼亚大学圣地亚哥妊娠合并糖尿病的产前门诊。糖尿病的诊断是依据糖尿病的产前诊断或产后6周2小时葡萄糖耐量试验异常确定的。20周前妊娠终止者除外。HbAle用Bio-Rad Diamat分析系统测定,正常值的上限为6.1％。首次测定HbAlc的平均孕龄为15.3±8.5周。所有病人在 Diabetic mothers with neonatal congenital abnormalities than normal pregnancy 3 to 5 times. Diabetes is not well controlled on the basis of increased HbAlc and is associated with an increased risk of fetal structural abnormalities. About half of these anomalies are congenital heart defects. When Miller et al found that the first HbA1c value is higher than 8.5%, the risk of neonatal congenital abnormalities in diabetic mothers is significantly increased. The subjects were from January 1985 to April 1992, visiting prenatal clinics of pregnancy-associated diabetes in the University of California, San Diego. The diagnosis of diabetes is based on a prenatal diagnosis of diabetes or a 2-hour glucose tolerance test abnormalities at 6 weeks postpartum. 20 weeks before the termination of pregnancy except. HbAle was assayed on a Bio-Rad Diamat system with a normal upper limit of 6.1%. The mean gestational age at which HbA1c was first determined was 15.3 ± 8.5 weeks. All patients are there