树枝状高分子(Dendrimer)是一类具有三维结构的高分子,因其链骨架有许多末端,结构形状象树枝而得名。与其他线性或枝化高分子相比具有高度的几何对称性、精确的分子结构、大量的官能团、分子内存在空腔及分子链增长具有可控性等特点。这些特点使其在许多领域有潜在的重要应用价值,成为相关领域的研究热点。如药物载体、基因转移、医疗诊断、表面活性剂、催化剂载体等。因此,研究出一种新型的树枝状高分子,具有重要的意义。目前常用的树枝状高分子的合成方法包括固相法及液相法。应用一种新思路把两者优点相结合,以甘氨酸为核,通过设计合成了末端为氨基的新的扇形树枝状高分子化合物,同时研究了它作为生物医用材料中的非病毒载体的性能。 Dendrimers are a class of polymers with three-dimensional structures that derive their name from the structure of many branches and branches. Compared with other linear or branched macromolecules, they have high geometric symmetry, precise molecular structure, a large number of functional groups, cavity in the molecule and controllability of molecular chain growth. These features make it potentially useful in many fields and become a research focus in related fields. Such as drug carriers, gene transfer, medical diagnostics, surfactants, catalyst carriers and the like. Therefore, to develop a new type of dendrimer, has important significance. The currently used dendrimer synthesis methods include solid-phase method and liquid phase method. A new idea was put forward to combine the advantages of the two with glycine as nucleus. A new fan-shaped dendrimer with amino group at the end was designed and synthesized, and its performance as a non-viral vector in biomedical materials was also studied.