【摘 要】
：
肿瘤导致的骨软化症(tumor induced osteomalacia,TIO)是一种低血磷性骨软化症,由磷酸盐尿性间叶组织肿瘤(phosphaturic mesenchymal tumor,PMT)分泌过多的成纤维细胞生长因
【机 构】
：
中国医学科学院北京协和医学院北京协和医院内分泌科卫生部内分泌重点实验室,中国医学科学院北京协和医学院北京协和医院核医学科,中国医学科学院北京协和医学院北京协和医院放射科,中国医学科学院北京协和医学院北
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肿瘤导致的骨软化症(tumor induced osteomalacia,TIO)是一种低血磷性骨软化症,由磷酸盐尿性间叶组织肿瘤(phosphaturic mesenchymal tumor,PMT)分泌过多的成纤维细胞生长因子-23(fibroblast growth factor-23,FGF23)致肾脏漏磷增多,血磷降低,影响骨骼矿化所致,为获得性骨软化症的一种。1947年
Tumor-induced osteomalacia (TIO) is a hypophosphatemic osteomalacia that is secreted by the phosphaturic mesenchymal tumor (PMT) to produce excessive fibroblast growth factor- 23 (fibroblast growth factor-23, FGF23) caused by renal leakage of phosphorus, decreased serum phosphorus, affecting bone mineralization caused by acquired osteomalacia. 1947
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