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目的:评价高血压患者血管内皮功能的改变及氯沙坦的影响。方法:随机选择原发性高血压患者40例,检测其内皮素(ET)、心钠素(ANP)和一氧化氮(NO)水平的变化。结果:与正常对照组比较,高血压组患者ET、ANP水平上升明显(P均<0.05),NO水平明显下降(P<0.05),氯沙坦治疗后ET水平无明显变化,ANP下降明显(P<0.05),NO水平上升明显(P<0.05)。结论:高血压患者血管内皮功能有明显变化.氯沙坦不仅有较好的降压作用,可能也有较好的血管内皮保护功能。
Objective: To evaluate the changes of vascular endothelial function in hypertensive patients and the influence of losartan. Methods: Forty patients with essential hypertension were randomly selected to detect the changes of ET, ANP and NO levels. Results: Compared with the normal control group, the levels of ET and ANP in hypertensive patients increased significantly (P <0.05) and the levels of NO decreased significantly (P <0.05), while those in losartan did not change significantly and ANP decreased significantly P <0.05), NO level increased significantly (P <0.05). Conclusion: Hypertension patients have obvious changes of vascular endothelial function, losartan not only has better antihypertensive effect, may also have better vascular endothelial protection.