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新风轮菜属植物Calamintha sylvatica sub-sp acendens具有镇痉的抗组胺作用。本文报道了该植物精油中的主成分胡薄荷酮(pulc-gone)在离体豚鼠回肠上的抗组胺作用,并与抗组胺药美吡拉敏和右氯苯拉敏作了比较。胡薄荷酮2.4×10~(-7),4.8×、10~(-7),7.2×10~(-7)mol均可使组胺累加,浓度反应曲线右移,即增加组胺的ED_(50)。此作用与H_1-受体拮抗剂美吡拉敏和右旋氯苯吡胺一致。胡薄荷酮的抗组胺作用随剂量增加而增强。含胡薄
The new genus Calamintha sylvatica sub-sp acendens has anti-histamine effect of antispasmodic. This article reports the antihistaminic effect of the pulch-derived main ingredient in the plant essential oil on isolated ileum of guinea pigs and compares them with the antihistamines, mepyramine and dexchlorpheniramine. Histamine could be accumulated by 2.4 × 10 ~ (-7), 4.8 ×, 10 ~ (-7) and 7.2 × 10 ~ (-7) mol respectively, and the concentration response curve shifted to the right, (50). This effect is consistent with the H 1 -receptor antagonists mepyramine and dexrambexamine. Anti-histamine effects of pulegone increased with dose. Containing thin