脑内肽(P 物质和加压素等)是与人们的学习和记忆密切相关的物质。脯氨酰内肽酶(PEP)是使脑内肽水解、作用失活的酶。最近在阿尔茨海默病患者脑组织中发现该酶的活性增加,说明它与该病特有的淀粉样蛋白的生成有关,因此推测 PEP 抑制剂能成为阿尔 Intracerebral peptides (P substances, vasopressin, etc.) are closely related to people’s learning and memory. Prolyl endopeptidase (PEP) is an enzyme that hydrolyzes and inactivates peptides in the brain. The activity of this enzyme was recently increased in brain tissue of patients with Alzheimer’s disease, suggesting that it is related to the production of amyloid that is unique to the disease, so it is speculated that PEP inhibitors can become