有机羧酸在气态、液态或在憎质子溶剂(如苯、萘等……)中显著的缔合性质,现在知道主要由于分子间形成O-H…O氢键的结果。许多研究证明当分子内有可能形成内氢键的钳环时,将显著地改变或减弱分子缔合的性质。在芳香族化合物中,这方面的例子已经研究的很多。根据氢键主要是在负电性较强的原子之间形成,氟原子是负 Organic carboxylic acids in the gaseous, liquid or in a proton-solvent (such as benzene, naphthalene, etc.) significant association properties, now know mainly due to the formation of O-H ... O hydrogen bonds between molecules results. Numerous studies have demonstrated that when there is a clamp ring in the molecule that is likely to form an internal hydrogen bond, the nature of molecular association will be significantly altered or diminished. In the case of aromatics, examples in this area have been studied extensively. Hydrogen bonds are formed primarily between the more negatively charged atoms, and the fluorine atoms are negative