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目的探讨氯沙坦联合合贝爽治疗肥厚型心肌病(HCM)的疗效及安全性。方法23例HCM病人口服氯沙坦和合贝爽,氯沙坦50mg/d,合贝爽90mg/d,疗程6个月。观察治疗前后临床症状、心电图、心脏彩超检查的变化。结果治疗后临床症状减轻,心电图倒置T波深度减少或变为直立,室间隔或室壁厚度下降,总有效率分别为86.90%、69.56%和52.17%。结论氯沙坦联合合贝爽治疗肥厚型心肌病安全有效,易于坚持治疗。
Objective To investigate the efficacy and safety of losartan combined with chuanbeihuang in the treatment of hypertrophic cardiomyopathy (HCM). Methods Twenty-three patients with HCM were treated with Losartan and Copeparin, losartan 50mg / d and Bupo-Shuang 90mg / d for 6 months. Before and after treatment to observe the clinical symptoms, ECG, cardiac color Doppler ultrasound examination changes. Results After treatment, the clinical symptoms were relieved. The depth of inverted T wave was reduced or turned upright and the ventricular septum or wall thickness decreased. The total effective rates were 86.90%, 69.56% and 52.17%, respectively. Conclusion Losartan combined with Pui Shuang treatment of hypertrophic cardiomyopathy safe and effective, easy to adhere to the treatment.