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为解决组织器官移植中的排斥问题,极大地推动了人体白细胞抗原系统(Human LeucocyteAntigen,HLA)研究的进展。通过7次世界性的组织相容性试验专题讨论会(以下简称会议),HLA的一些基本规律已被阐明.HLA的概念从代表染色体上的一个组织相容性位点A(Histocompatibility Locus-A,HL-A)扩大到代表整个HLA遗传区域。HLA遗传区域由一系列紧密连锁的基因组成,控制特异的免疫反应、细胞表面决定簇、免疫相关抗原以及某些补体组分等,它实际上就是人体的主要组织相容性复合体(Major histocompatibilitycomplex,MHC)。其主要产物,用血清学方法检出的有:存在所有有核细胞膜上的受HLA-A、B、C
To solve the problem of rejection in tissue and organ transplantation, the progress of research on human leucocyte antigen system (HLA) has been greatly promoted. Through the seven worldwide symposium on histocompatibility compatibility (hereinafter referred to as the conference), some basic rules of HLA have been elucidated.The concept of HLA is derived from a histocompatibility locus A (Histocompatibility Locus-A , HL-A) expanded to represent the entire HLA genetic region. HLA genetic region by a series of closely linked genes, control specific immune response, cell surface determinants, immune-related antigen and some complement components, it is actually the body’s major histocompatibility complex , MHC). Its main products, detected by serological methods are: the existence of all nucleated cell membrane by HLA-A, B, C