异搏停(Verapamil)作为钙拮抗剂的一种类型,已较广泛地应用于心血管系统,有关其对肾脏生理及急性肾功能衰竭影响的研究也有报道。近年来,又有许多学者就异搏停对膀胱收缩的影响及其临床应用方面进行了一系列的研究,现将有关内容综述如下: 一、异搏停对离体逼尿肌收缩能力的影响早在1982年Finkbeinef等就报道了异搏停对豚鼠离体逼尿肌收缩能力的影响,以后又有类似的报道,虽然所采用的研究对象及观察手段稍有 Verapamil, a type of calcium antagonist, has been widely used in the cardiovascular system. Studies on its effects on renal physiology and acute renal failure have also been reported. In recent years, many scholars have carried out a series of researches on the influence of verapamil on bladder contraction and its clinical application. The relevant contents are summarized as follows: First, the influence of verapamil on the contractility of isolated detrusor As early as 1982, Finkbeinef et al. Reported the effect of verapamil on the contractile ability of isolated detrusor in guinea pigs. Later similar reports were reported. Although the study subjects and observation methods used were slightly