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动物实验表明,肾脏低灌注对小剂量多巴胺可刺激肾内特异性受体而使肾皮质血管扩张。另一方面,速尿可导致扩张血管的前列腺素合成。因此两药联合应用似能防止少尿。为证明此点,作者对16例曾用甘露醇和大剂量速尿不能利尿的急性肾衰竭(15例发生于手术后,1例于产后)和3例肝肾综合征静脉滴注亚药理学剂量的多巴胺3μg/kg/min和速尿10～15mg/kg/h,经6～24小时全部病例均出现明显利尿(由
Animal experiments show that renal hypoperfusion on small doses of dopamine can stimulate renal specific receptors and renal cortical blood vessels dilation. Furosemide, on the other hand, can lead to prostaglandin synthesis of dilated blood vessels. Therefore, the joint application of two drugs can prevent oliguria. In order to prove this point, the author of 16 cases of acute renal failure who had used mannitol and high-speed furosemide diuretic (15 cases occurred after surgery, 1 case postpartum) and 3 cases of hepatorenal syndrome intravenous sub-pharmacological dose Of dopamine 3μg / kg / min and furosemide 10 ~ 15mg / kg / h, after 6 ~ 24 hours all cases were significant diuretic (from