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(1)本文报导试用保泰松治疗急性血吸虫病发热40例,有效率达95％。 (2)成人剂量,轻型病例每日0.3—0.4克,较重病例每日0.6—0.8克,分3—4次口服,一般疗程1—2周,服药期间应给予低盐饮食。 (3)保泰松对各种类型血吸虫病,均有退热疗效,多在三日内降达正常,从而显著缩短本病热程,改善症状,有利于早日接受锑剂治疗。但对病原并无直接作用,若单用该药,停药后仍有发热。 (4)本药反应轻微,但有45％患者服药后产生浮肿,可能系血电解质紊乱及患者血浆蛋白低下等综合因素有关。停药或改用无盐饮食,多自行消退。 (5)该药经济简便,退热显著,毒性低微,值得临床研究应用.
(1) This article reports the trial Phenylbutazone treatment of acute schistosomiasis fever 40 cases, the effective rate of 95%. (2) Adult doses, light cases 0.3-0.4 grams daily, heavier cases 0.6-0.8 grams daily, 3-4 times orally, the general course of 1-2 weeks, medication should be given low-salt diet. (3) Phenylbutazone on all types of schistosomiasis, have antipyretic efficacy, and more than three days to reach the normal, thereby significantly reducing the fever of the disease, improve symptoms, is conducive to the early receipt of antimony agent treatment. But no direct effect on the pathogen, if the drug alone, there are still fever after stopping. (4) The drug response is mild, but 45% of patients edema after taking the drug may be related to blood electrolyte imbalance and plasma protein synthesis and other factors. Stop drug or switch to non-salt diet, and more subsided. (5) The drug is simple and economic, fever is significant, low toxicity, it is worth clinical application.