论文部分内容阅读
建立放射免疫分析方法，对出血性（ＨＣＶＤ，ｎ＝１０），缺血性（ＩＣＶＤ，ｎ＝３１）脑血管病急性期患者，以及健康对照者（ｎ＝１０）的血浆肾上腺髓质素前体（ＰｒｏＡｄＭ１５３－１８５）含量进行了研究发现，ＨＣＶＤ组血浆ＰｒｏＡｄＭ１５３－１８５含量显著高于对照组及ＩＣＶＤ组（分别Ｐ＜０．０５及＜０．０１），ＩＣＶＤ组与对照组之间则无显著差异（Ｐ＞０．０５）。在ＩＣＶＤ组中，大灶皮层梗塞患者血浆ＰｒｏＡｄＭ１５３－１８５含量又显著高于皮层下梗塞患者（Ｐ＜０．０１），发病后第３ｄ的患者血浆ＰｒｏＡｄＭ１５３－１８５含量显著高于第１ｄ及第２ｄ的患者（分别Ｐ＜０．０５，０．０１）。提示ＰｒｏＡｄＭ１５３－１８５在脑血管疾病的病理过程中具有作用。
A radioimmunoassay was established to evaluate the effect of plasma adrenomedullin on hemorrhagic (HCVD, n = 10), ischemic (ICVD, n = 31) patients with acute cerebrovascular disease and healthy controls (n = 10) (ProAdM153-185) content was found in HCVD group plasma ProAdM153-185 content was significantly higher than the control group and ICVD group (P <0.05 and <0.01, respectively), ICVD group and the control group without Significant difference (P> 0.05). In the ICVD group, plasma ProAdM153-185 levels in patients with COPD were significantly higher than those in patients with subcortical infarcts (P <0.01). The levels of ProAdM153-185 in the third day after onset were significantly higher than those in the first and second days Patients (P <0.05, 0.01, respectively). Tip ProAdM153-185 plays a role in the pathological process of cerebrovascular disease.