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本实验对38只家兔的 IAN 行不同程度的损伤:切断、缺损4mm 和8mm.通过扫描电镜、神经电生理,组织学、HRP 组织化学方法.在术后1—7月内不同时期,定性定量地观察 IAN 在下颌管内的自身修复能力、下颌管与神经再生的关系以及节细胞对轴突损伤和再生的反应.结果显示,下颌神经管的存在和通畅有利于再生神经纤维通过损伤间隙,即使是缺损8mm.仍有较高程度的神经再生和功能恢复,节细胞标志率以切断组最高,两缺损组较低并呈胞体长期代偿性肥大。
In this study, IAN of 38 rabbits were sacrificed to varying degrees: 4 mm and 8 mm defects were cut off, and examined by scanning electron microscopy, electrophysiology, histology and HRP histochemistry at different time points after 1 to 7 months Quantitatively observe the IAN self-repair ability in the mandibular canal, the relationship between mandibular canal and nerve regeneration and the response of ganglion cells to axonal injury and regeneration.The results show that the existence and patency of mandibular neural tube is conducive to the regeneration of nerve fibers through the injury gap, Even with a defect of 8 mm, there was still a higher degree of nerve regeneration and functional recovery, with the highest rate of ganglion cell markers in the severed group and the two defect groups with low and long term compensatory hypertrophy of the soma.