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右心室流出道室性心律失常是临床上常见的特发性心律失常,占特发性室速的60%~70%,绝大多数右心室流出道室速为腺苷敏感性,其发病机制为儿茶酚胺介导的延迟后除极和触发活动。其发生机制一直是电生理领域研究的热点问题,新近研究表明,L型钙通道的改变与特发性右心室流出道室性心动过速的发生密切相关,提示L型钙通道可能会成为特发性右心室流出道室性心动过速治疗的新靶点。
Right ventricular outflow tract ventricular arrhythmia is clinically common idiopathic arrhythmia, accounting for 60% to 70% of the idiopathic VT, the vast majority of right ventricular outflow tract ventricular rate of adenosine sensitivity, the pathogenesis For catecholamine-mediated delayed depolarization and triggering activity. Its mechanism has been a hot issue in the field of electrophysiology, recent studies have shown that changes in L-type calcium channels and occurrence of idiopathic RV ventricular tachycardia are closely related, suggesting that L-type calcium channels may become special A new target for the treatment of ventricular tachycardia in patients with paroxysmal right ventricular outflow tract.