癫痫发作后脑部易感区域神经元的死亡,从而导致患者的认知功能出现损害,有实验研究证明Bcl-2基因家族蛋白在癫痫发作后神经元死亡的信号分子通路中发挥着重要的作用,并且癫痫发作后认知功能的损害可能与Bcl-2基因家族蛋白的水平相关,因此监测颅内或外周组织中Bcl-2基因家族蛋白水平的变化情况可以反映出癫痫发作后认知功能损害的程度,以便临床能够早期进行适当的干预,从而减轻患者认知功能损害的程度。 Experimental studies have shown that Bcl-2 gene family proteins play an important role in signaling pathways of neuronal death after epileptic seizures, leading to neuronal death in susceptible brain regions after epileptic seizures, leading to impaired cognitive function in patients , And the impairment of cognitive function after seizure may be related to the level of Bcl-2 gene family protein. Therefore, monitoring the changes of Bcl-2 gene family in intracranial or peripheral tissues may reflect the impairment of cognitive function after seizure So that the clinic can make the appropriate intervention in the early stage so as to reduce the degree of cognitive impairment in patients.