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为了了解木尘对机体细胞免疫的影响,作者选用小鼠研究了桦木和柳桉木的混合尘对外周血T淋巴细胞数、免疫器官脾和胸腺的脏器系数、以及T淋巴细胞功能的影响。共设三个剂量组(10、5、0.5g/kg),一个溶剂对照组和一个阳性对照组,连续五天染毒,第六天取样观察。结果发现,各剂量组的外周血淋巴细胞ANAE+率显著性低于溶剂对照组(P<0.01),且有剂量反应关系(r=-0.87);最高剂量组的脾脏脏器系数和脾细胞总数减少,与溶剂对照组相比较有显著性差异(P<0.05)。提示桦木和柳桉木的混合尘可引起小鼠外周血T淋巴细胞数、脾脏重量和脾细胞总数下降,但未见对脾脏T淋巴细胞功能有影响。可以认为,桦木和柳桉木的混合尘对小鼠的细胞免疫是有影响的。
In order to understand the effect of wood dust on cellular immunity, we selected mice to study the effects of mixed dust of birch and willow wood on the number of T lymphocytes in peripheral blood, the organ coefficient of spleen and thymus in immune organs, and the function of T lymphocytes. A total of three dose groups (10, 5, 0.5 g / kg), a solvent control group and a positive control group were exposed for five consecutive days and sampled on the sixth day. The results showed that the ANAE + rate of peripheral blood lymphocytes in each dose group was significantly lower than that in the solvent control group (P <0.01), and there was a dose response relationship (r = -0.87). The spleen organ coefficient And the total number of spleen cells decreased, compared with the solvent control group was significantly different (P <0.05). Tip birch and willow mixed dust can cause mice peripheral blood T lymphocytes, spleen weight and the total number of splenocytes decreased, but no effect on the splenic T lymphocyte function. It is believed that the mixed dust of birch and willow has effects on the cellular immunity of mice.