氟代糖苷类化合物具有明显的抗肿瘤、抗病毒及其它生物活性。其中较突出的是高选择性的抗病毒药氟碘阿糖胞苷(FIAC)。这类化合物的合成,关键的问题是糖上羟基的氟化。由于氟离子的亲核能力低,并会诱发消除等副反应,因而造成反应复杂、收率低。近年来发展起来的二乙胺基三氟化硫(DAST)是一 Fluoroglucosides have obvious anti-tumor, anti-virus and other biological activity. One of the more prominent is the highly selective antiviral drug fluoroiodocytoside (FIAC). The key issue in the synthesis of these compounds is the fluorination of hydroxyl groups on the sugar. Due to the low nucleophilic capacity of fluoride ions, and will lead to the elimination of side effects, resulting in complex reactions, low yields. Diethyl ammonium sulfur trifluoride (DAST) has been developed in recent years