【摘 要】
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Fluorescein angiography (FA) is a standard imaging modality for evaluating vascular abnormalities in retina-related diseases,which is recognized as the major cause of vision loss.Long-term and real-time fundus angiography is of great importance in preclin
【机 构】
：
Laboratory of Nanoscale Biochemical Analysis,Institute of Functional Nano and Soft Materials (FUNSOM
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Fluorescein angiography (FA) is a standard imaging modality for evaluating vascular abnormalities in retina-related diseases,which is recognized as the major cause of vision loss.Long-term and real-time fundus angiography is of great importance in preclinical research,nevertheless remaining big challenges up to present.In this study,we demonstrate that long-term fluorescence imaging of retinal vessels is enabled through a kind of fluorescent nanoagents,which is made of small-sized (hydrodynamic diameter:～ 3 nm)silicon nanoparticles (SiNPs) featuring strong fluorescence,robust photostability,lengthened blood residency and negligible toxicity.In particular,the presented SiNPs-based nanoagents are capable of imaging retinal capillaries in ～ 10 min,which is around 10-fold longer than that (～ 1 min) of fluorescein sodium (FS,known as the most widely used contrast agents for FA in clinic).Taking cynomolgus macaques as non-human primate-animal model,we further demonstrate the feasibility of real-time diagnosis of retinal diseases (e.g.,age-related macular degeneration (AMD)) through dynamic monitoring of vascular dysfunction.
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