论文部分内容阅读
目的了解无锡市儿童医院住院患儿肠球菌的临床分布及耐药特点,为经验治疗提供参考。方法对该院2012-2016年住院患儿送检标本分离出的病原菌进行细菌鉴定和药敏分析,运用WHONET 5.4软件进行统计分析。结果7 414株病原菌中革兰阳性菌有3 469株,其中肠球菌383株,占11.04%(383/3 469)。肠球菌中屎肠球菌273株,粪肠球菌105株,鸟肠球菌5株,分别占71.28%、27.42%及1.30%;主要分布在28 d~1岁及≤28 d患者。主要标本来源为尿液(75.46%),其次为血液(9.66%)。科室来源以新生儿科和儿肾内科为主,分别占27.15%、23.24%。屎肠球菌和粪肠球菌对万古霉素、利奈唑胺和呋喃妥因的耐药率分别为0.73%、2.20%、8.79%及0、0.95%、1.90%;对青霉素及氨苄西林耐药率分别为96.70%、94.87%及2.86%、1.90%。结论住院患儿分离的肠球菌属以屎肠球菌为主,婴儿为主要分离人群,泌尿道为易感部位。屎肠球菌和粪肠球菌对万古霉素、利奈唑胺和呋喃妥因敏感,其中耐利奈唑胺菌株检出率高于耐万古霉素菌株,应引起重视。
Objective To understand the clinical distribution and drug resistance characteristics of enterococci inpatients in Wuxi Children’s Hospital and provide reference for experience treatment. Methods Bacterial identification and drug susceptibility analysis of pathogenic bacteria isolated from inpatients admitted to our hospital from 2012 to 2016 were carried out. The data were analyzed by WHONET 5.4 software. Results There were 3 469 Gram-positive bacteria in 7 414 pathogens, including 383 Enterococcus (accounting for 11.04% (383/3 469)). Enterococcus faecium Enterococcus faecium 273, Enterococcus faecalis 105, Escherichia coli five strains, accounting for 71.28%, 27.42% and 1.30%, respectively; mainly distributed in 28 d ~ 1 year old and ≤ 28 d patients. The main source of sample urine (75.46%), followed by blood (9.66%). Department of neonatal and pediatric nephrology based, respectively, accounting for 27.15%, 23.24%. Enterococcus faecalis and Enterococcus faecalis vancomycin, linezolid and nitrofurantoin resistance rates were 0.73%, 2.20%, 8.79% and 0,0.95%, 1.90%; penicillin and ampicillin resistance rates were 96.70%, 94.87% and 2.86%, 1.90% respectively. Conclusion Enterococci isolated from hospitalized patients are Enterococcus faecium, with infants as the main separated population and urinary tract as susceptible sites. Enterococcus faecalis and Enterococcus faecalis were sensitive to vancomycin, linezolid and nitrofurantoin, and the detection rate of linezolid resistant strains was higher than that of vancomycin resistant strains.