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【钙的病理生理作用】钙对气道的生理作用;①化学介质的释放:细胞外 Ca~(++)内流引起抗原介导的免疫性释放,细胞内 Ca~(++)的动员引起48/80-介导的非免疫性释放;Ca~(++)刺激5-脂氧酶(即白三烯途径的起始酶)促进介质的合成。②气管支气管分泌:细胞内、外 Ca~(++)的升高,或细胞外Ca~(++)的降低(?),都能引起气道粘液下腺的粘液细胞和浆细胞的糖蛋白分泌增加。③电介质分泌:细胞外 Ca~(++)降低,引起电阻减小,对组织胺的短程电路电流反应性降低;细胞内 Ca~(++)升高,通过 Ca~(++)载体A23187引起氯分泌增加,钠转运阻断。④细胞内 Ca~(++)
[Pathophysiological role of calcium] physiological effects of calcium on the airway; (1) release of chemical mediators: extracellular Ca ~ (++) influx leads to antigen-mediated immune release, intracellular Ca ~ (++) mobilization Causing 48/80-mediated non-immune release; Ca ~ (++) stimulates 5-lipoxygenase, the starting enzyme for the leukotriene pathway, to promote media synthesis. ② tracheal bronchial secretion: intracellular and extracellular Ca ~ (++) increased, or extracellular Ca ~ (++) decreased (?), Can cause airway mucus gland mucus cells and plasma cells of sugar Increased protein secretion. (3) Dielectric secretion: the decrease of extracellular Ca ~ (++) resulted in the decrease of resistance and the short circuit current reactivity to histamine decreased; Ca ~ (++) increased in Ca ~ (++) vector A23187 Cause increased chloride secretion, sodium transport block. ④ intracellular Ca ~ (++)