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拉莫三嗪(LTG)是一种化学结构与其他抗癫痫药物不同的新型抗癫痫药。研究表明LTG作用于电压敏感的钠通道而稳定神经元细胞膜,作用与卡马西平(CBZ)相似,均可减少钙内流,CBZ可诱导加压素异常分泌,改变下丘脑渗透压受体对血浆渗透压的敏感性而引起低钠血症。
Lamotrigine (LTG) is a novel anti-epileptic drug whose chemical structure is different from other antiepileptic drugs. Studies have shown that LTG acts on voltage-sensitive sodium channels and stabilizes the neuronal cell membrane, which is similar to carbamazepine (CBZ) and can reduce the influx of calcium. CBZ can induce the abnormal secretion of vasopressin and change the hypothalamic osmoregulation Plasma osmolality caused by the sensitivity of hyponatremia.