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氚气和溶液中有机分子之间的同位素交换被认为是在有催化剂存在下发生的一种新的交换法。近来报导了采用铂黑、钯黑或者PdO/BaSO_4等作为催化剂的交换反应,在这种类型的交换反应中,发现PdO/BaSO_4是最有效的催化剂,所有容易标记的位置都在靠近高电子云密度中心附近。根据文献报导在嘌呤类化合物中,氚标记在嘌呤环的第八位碳原子上。 这种新的交换法是在有催化剂存在下,将氚气和溶液中的有机分子接触,而引起氚-氕同位素交换。它具有操作简便,催化交换效率高,而且不需要受前体来源困难的限制,可以制得高比度标记物等优点,可以
The isotope exchange between tritium gas and organic molecules in solution is considered to be a new exchange method that occurs in the presence of a catalyst. Recently, exchange reactions using platinum black, palladium black or PdO / BaSO 4 as catalysts have been reported. In this type of exchange reaction, PdO / BaSO 4 is found to be the most effective catalyst and all the easily labeled sites are near the high electron cloud Near the density center. According to the literature reported in the purine compounds, tritium marked purine ring eighth carbon atoms. The new exchange method is to contact the tritium gas with the organic molecules in solution in the presence of a catalyst to cause the exchange of tritium-氕 isotopes. It has the advantages of simple operation, high catalytic exchange efficiency, no need to be limited by the difficulty of source of precursor and the advantages of high specific labeling and the like.