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了解群体反应性抗体在肾移植中的意义。方法观察了群体反应性抗体（ＰＲＡ）与肾移植术后排斥反应关系。结果发现ＰＲＡ阳性及其强度与排斥反应相关：ＰＲＡ阳性率１３．３％，阴性率为１．４％（Ｐ＜０．０１）；阳性者总排斥率为３５．６％，阴性为７．２％（Ｐ＜０．０１）；ＰＲＡ＞３０％时排斥率７０．６％，而＜２９％时为１４．３％（Ｐ＜０．０１）。首次移植ＰＲＡ阳性率１２．２％，再次移植阳性率７１．４％。女性ＰＲＡ阳性高于男性。再次移植、反复输血及妊娠是致敏重要因素。结论ＰＲＡ应作为术前组织配型的一种方法。ＰＲＡ检测对提高肾移植存活率有帮助；同时讨论了ＰＲＡ阳性者作肾移植前的处理方式
Understand the significance of population reactive antibody in renal transplantation. Methods The relationship between group reactive antibody (PRA) and rejection after renal transplantation was observed. The results showed that PRA positive and its intensity correlated with rejection: the positive rate of PRA was 13.3% and the negative rate was 1.4% (P <0.01). The positive rate of rejection was 35.6% and the negative rate was 7. 2% (P <0.01). The rate of rejection was 70.6% at PRA> 30% and 14.3% (P <0.01) at <29%. The first positive rate of transplanted PRA was 12.2% and the positive rate of retransplantation was 71.4%. Female PRA positive than male. Transplantation, repeated blood transfusion and pregnancy are important factors of sensitization. Conclusion PRA should be used as a preoperative tissue matching method. PRA test to improve the survival rate of renal transplantation is helpful; at the same time discussed PRA positive for kidney transplantation before treatment