【摘 要】
：
The aim of this study is to investigate the protective effects of a small molecular fraction (SMF) ofPolygoni multiflori Radix Praeparata (PMRP) in a cyclophosphamide (CTX) induced anemia mouse model.Small molecular fraction of PMRP was prepared and ident
【机 构】
：
Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University
论文部分内容阅读
The aim of this study is to investigate the protective effects of a small molecular fraction (SMF) ofPolygoni multiflori Radix Praeparata (PMRP) in a cyclophosphamide (CTX) induced anemia mouse model.Small molecular fraction of PMRP was prepared and identified by high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS).In pharmacology,we examined the peripheral hemogram and thymus and spleen index.The content of granulocyte-macrophage colony-stimulating factor (GM-CSF) in serum was mensurated by enzyme-linked immunosorbent assay (ELISA);The level of superoxide dismutase (SOD),catalase (CAT),total antioxidant capacity (T-AOC),and malondialdehyde (MDA) in serum and spleen tissue homogenate were detected,and glutathione peroxidase (GSH-PX) was assayed in spleen.The results show that SMF can significantly accelerate the recovery of peripheral hemogram,increase the activity of antioxidant enzymes and GM-CSF in serum and spleen.SMF also increases the number of spleen cells,improves bone marrow pathology.In conclusion,the SMF of PMRP promoted the recovery of hematopoietic function in a CTX-induced anemia mouse,which can support SMF to be used as an adjunct to chemotherapy to counteract its side effects.
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