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目的探讨慢性心力衰竭(CHF)患者血浆血管紧张素Ⅱ(AngⅡ)、醛固酮水平(Ald)含量变化与左室平均室壁应力(mean wall stress,MWS)的相关性分析及临床意义。方法应用放射免疫法测定20例正常人和61例慢性充血性心力衰竭患者血浆血管紧张素Ⅱ、醛固酮含量,心脏超声测定左室收缩/舒张内径及室壁厚度并计算平均室壁应力。结果 CHF患者血浆血管紧张素Ⅱ、醛固酮含量较正常对照组明显升高,并随着心功能等级的增加而有升高趋势。血浆血管紧张素Ⅱ、醛固酮含量与左室平均室壁应力呈正相关。结论慢性心力衰竭患者血清血浆血管紧张素Ⅱ、醛固酮含量的变化及室壁应力增加参与慢性心力衰竭致病机制,它们之间可能还有相互作用及影响,共同参与慢性心力衰竭的致病机制。
Objective To investigate the relationship between plasma angiotensin Ⅱ (AngⅡ), aldosterone (Ald) content and mean wall stress (MWS) in patients with chronic heart failure (CHF) and its clinical significance. Methods The plasma levels of angiotensin Ⅱ and aldosterone were measured in 20 normal subjects and 61 patients with chronic congestive heart failure by radioimmunoassay. Left ventricular systolic / diastolic diameter and wall thickness were measured by echocardiography and mean wall stress was calculated. Results The plasma levels of angiotensin Ⅱ and aldosterone in CHF patients were significantly higher than those in normal controls and increased with the increase of cardiac function. Plasma angiotensin Ⅱ, aldosterone content and left ventricular average wall stress was positively correlated. Conclusion The changes of plasma angiotensin Ⅱ and aldosterone levels in patients with chronic heart failure and the increase of wall stress may participate in the pathogenesis of chronic heart failure. There may be interactions and influences between them, which may participate in the pathogenesis of chronic heart failure.