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用RIA对45例流行性出血热患者进行了β_2-MG 测定。结果显示:各病期内β_2-MG 非常显著升高,抗β_2-MG 阴性;尿β_2-MG 排量超过正常人排量万倍以上;血、尿β_2-MG 于病后二月渐趁正常,尿检阴性和阳性两组出血热患者的血β_2-MG 水平有显著差异,而尿β_2-MG 则两组间无显著差异。以上表明,EHF有别于免疫性肾脏疾患,具有自限性。也表明 EHF 可能存在免疫调控失灵所致的β_2-MG 合成增多;EHF 患者肾小管病损并非纯系继发性缺血性改变,而可能与肾小管的直接病损有关。
Forty-five patients with epidemic hemorrhagic fever were assayed for β_2-MG using RIA. The results showed that β_2-MG was significantly increased and anti-β_2-MG was negative in all stages of disease; urinary β_2-MG was more than ten thousand times more than normal; , Urine test negative and positive hemorrhagic fever patients with blood β_2-MG levels were significantly different, while urinary β_2-MG was no significant difference between the two groups. The above shows that, EHF is different from immune kidney disease, with self-limiting. Also showed that EHF may exist immune regulation failure caused by increased β_2-MG synthesis; EHF patients with renal tubular lesion is not pure secondary ischemic changes, and may be related to the direct tubular damage.