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[目的]探讨肺结核合并糖尿病患者的治疗方法和治疗效果。[方法]将1997~2005年济源市疾病预防控制中心结核病防治门诊确诊的所有的肺结核患者1 529例患者分为2组,其中53例合并糖尿病者为糖尿病组,其余1 476例患者为对照组,2组均给予2HRZE/4H3R3或2H3R3Z3E3/4H3R3方案治疗,比较其治疗效果。[结果]痰菌阴转率,治疗2个月、3个月糖尿病组分别为62.22%、75.56%,对照组分别为85.80%、92.41%(P<0.01);疗程结束时糖尿病组为86.67%,对照组为92.74%(P>0.05)。症状消失或明显改善时间,糖尿病组为43.00±7.51 d,对照组为20.00±5.58d(P<0.05);疗程糖尿病组为11.60±2.58个月,对照组为7.20±1.21个月(P<0.05)。疗程结束时胸片吸收好转率,糖尿病组为84.91%,对照组为87.47%(P<0.05)。治疗2个月、3个月时,空洞闭合者所占比例糖尿病组分别为11.43%、42.86%,对照组分别为29.79%、64.49%(P<0.05);疗程结束时2组分别为94.29%、96.10%(P>0.05)。[结论]肺结核合并糖尿病患者治疗较单纯肺结核困难,传染期延长,病变吸收缓慢,应积极采取措施治疗。
[Objective] To explore the treatment and treatment effect of tuberculosis complicated with diabetes. [Methods] A total of 1 529 pulmonary tuberculosis patients diagnosed in the TB prevention and treatment clinic of Jiyuan Municipal Center for Disease Control and Prevention from 1997 to 2005 were divided into two groups. 53 of them with diabetes mellitus were diabetic and the other 1 476 were control , 2 groups were given 2HRZE / 4H3R3 or 2H3R3Z3E3 / 4H3R3 regimen treatment, compare the treatment effect. [Results] The rate of sputum negative conversion rate was 62.22% and 75.56% in the two months and three months after treatment, respectively, 85.80% and 92.41% in the control group (P <0.01), respectively. At the end of the treatment period, the diabetes group was 86.67% , The control group was 92.74% (P> 0.05). Symptoms disappeared or significantly improved time, the diabetic group was 43.00 ± 7.51 d, the control group was 20.00 ± 5.58d (P <0.05); treatment diabetes group was 11.60 ± 2.58 months, the control group was 7.20 ± 1.21 months (P <0.05 ). At the end of the course of treatment, the improvement rate of chest radiographs was 84.91% in the diabetic group and 87.47% in the control group (P <0.05). At 2 months and 3 months after treatment, the percentage of empty closers was 11.43% and 42.86% in the diabetic group and 29.79% and 64.49% in the control group (P <0.05), respectively. At the end of the treatment period, the two groups were 94.29% , 96.10% (P> 0.05). [Conclusion] The treatment of patients with pulmonary tuberculosis complicated with diabetes is more difficult than simple tuberculosis, the infection period is prolonged, and the absorption of the disease is slow. Measures should be actively taken to treat it.