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目的探讨白细胞介素 - 2 (IL - 2 )、白细胞介素 - 6 (IL - 6 )在脑梗死发病中的作用。方法采用放射免疫法检测 48例急性脑梗死患者治疗前后和 2 0例动脉粥样硬化患者及 30例健康者血清IL - 2、IL - 6水平。结果脑梗死患者治疗前IL - 2水平显著低于正常对照组 (P <0 0 5 ) ,治疗 4周后显著升高 (P <0 0 5 ) ;IL - 6水平治疗前显著高于正常对照组 (P <0 0 5 ) ,治疗 4周后显著下降 (P<0 0 5 )。动脉粥样硬化患者与治疗后脑梗死患者相比差异无统计学意义。结论血清IL - 2、IL - 6水平不仅可作为判断脑梗死患者病情、治疗及预后的免疫学指标 ,且由于它们在动脉粥样硬化期已出现异常变化 ,因而也可作为缺血性卒中预防性检测的免疫学指标。
Objective To investigate the role of interleukin - 2 (IL - 2) and interleukin - 6 (IL - 6) in the pathogenesis of cerebral infarction. Methods Serum IL - 2 and IL - 6 levels were measured by radioimmunoassay in 48 patients with acute cerebral infarction before and after treatment and 20 patients with atherosclerosis and 30 healthy controls. Results The levels of IL - 2 in patients with cerebral infarction before treatment were significantly lower than those in normal controls (P <0.05), and significantly increased after 4 weeks of treatment (P <0.05). The levels of IL - 6 in patients with cerebral infarction before treatment were significantly higher than those in controls Group (P <0 05), after 4 weeks of treatment decreased significantly (P <0 05). There was no significant difference between atherosclerosis patients and those after treatment of cerebral infarction. Conclusion Serum levels of IL - 2 and IL - 6 can not only be used as an immunological index for judging the condition, treatment and prognosis of patients with cerebral infarction, but also as an ischemic stroke prevention due to their abnormal changes in the atherosclerosis stage Immunological indicators of sexual testing.