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1 历史回顾 1951年,Gubner应用白血宁治疗类风湿性关节炎时意外发现能使银屑病皮损消退,从而开创了抗癌药治疗银屑病的历史。不过当时用量较大,出现的毒性反应较重。后经探索,认为用小剂量已可治疗。在此基础上,国外先后用氨甲喋呤、博来霉素、羟基脲、6-MP、阿扎利宾及丙亚胺等抗癌药治疗银屑病,其中以氨甲喋呤使用得最为普遍。我国应用抗癌药治疗银屑病曾经形成过几个高峰。50年代末至60年代初是应用白血宁的高潮;1974年扬州会议后乙亚胺治疗银屑病形成第二个高峰;1983年杭州会议后乙双吗啉治疗银屑病空前普及,并一度曾处于失控状态。
1 History Review In 1951, Gubner’s application of leuricine for the treatment of rheumatoid arthritis found that psoriasis skin lesions subsided, thus creating a history of anticancer drug treatment of psoriasis. However, when the larger amount, the emergence of toxic reactions heavier. After exploration, that can be treated with a small dose. On this basis, psoriasis has been treated with anti-cancer drugs such as methotrexate, bleomycin, hydroxyurea, 6-MP, azaliplatin, and imide in foreign countries, of which methotrexate is most commonly used. China’s application of anti-cancer drugs for the treatment of psoriasis had formed several peaks. The late 50s to early 60s is the climax of the application of Xueuening; the second peak of pimostilmin treatment after the meeting was held in Yangzhou in 1974; B-morphine was unprecedented in the treatment of psoriasis after the Hangzhou meeting in 1983, Have been out of control.