近年,一种生物学效应温和而功能不明的癌基因v-erb-A曾一度被人忽视。随后,由于发现v-erb-A基因与编码固醇类激素受体基因结构上的亲缘性,就使该基因在调节后生动物细胞特殊功能的基因家族中获得了应有的地位。和其它逆转录病毒癌基因一样,v-erb-A由细的原癌基因c-erb-A转导而来,不同的是它与另一癌基因v-crb-B(由编码细胞表面表皮生长因子受体的基因转导而来)共存于AEV(avian erythroblastosis virus)病毒基因组中。AEV能引起鸡类 In recent years, a biologically mild but unknown oncoprotein v-erb-A was neglected. Subsequently, the discovery of the structural affinity of the v-erb-A gene to the gene encoding the steroid hormone receptor enabled the gene to take its place in the gene family that regulates the special functions of metazoan cells. Like other retroviral oncogenes, v-erb-A is transduced by the fine protooncogene c-erb-A except that it binds to another oncogene, v-crb-B, encoded by the cell surface epidermis Derived from the gene of growth factor receptor) coexist in the avian erythroblastosis virus genome. AEV can cause chicken